Research Thrusts

Currently, our lab focuses on advancing high-speed light field imaging technology and applying it to solve fundamental and translational problems in biomedicine. This core platform enables rapid 3D imaging with high temporal and spatial resolution, forming the foundation for three major research directions:

​

• Voltage Imaging
  We develop 3D kilohertz-rate voltage imaging techniques to optically record fast neural dynamics in vivo. Our systems are optimized for capturing membrane potential changes across distributed neuronal populations in behaving small animals, enabling new insights into brain function.

​​

• Short-Wave Infrared (SWIR) Imaging
  We pioneer high-speed, deep-tissue SWIR imaging for visualizing biological structures and functions in small animals. Our methods push the limits of imaging depth and speed, making them ideal for dynamic studies in neuroscience, oncology, and vascular biology.

​​

• Fluorescence Lifetime Imaging (FLIM)

We apply high-speed FLIM to translational biomedical challenges, including intraoperative biopsy guidance and high-throughput, label-free drug screening. Our work aims to bring quantitative metabolic imaging into real-time clinical workflows.

 

Together, these thrusts highlight our mission: to develop transformative imaging technologies that bridge the gap between optical engineering and biomedical discovery.